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Article

Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors.

Cancer research - 15 Aug 2025

Shan Jia-Lu, Zhang Kai-Ming, Zhong Wen-Qing, Yang Xiao-Yu, Li Zhi-Ling, Huang Yun, Du Tian, Yang Dong, Tang Jia-Hong, Chen Yu-Hong, Zhang Hai-Liang, Zhu Xiao-Feng, Deng Rong

Abstract excerpt

NRAS is commonly mutated in several different types of human cancer. NRAS-mutant tumors are aggressive and associated with poor outcomes. Although the development of targeted therapies as well as immune checkpoint inhibitors has led to a substantial improvement in the overall survival of patients with NRAS wild-type (WT) tumors, current therapies for NRAS-mutant cancers are limited. In this study, analysis of RNA...

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Source

Identifiers

PMID: 40392233
DOI: 10.1158/0008-5472.CAN-24-2983

Genes

NRAS
SOS1
CXCL10
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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