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Article

TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts

19 May 2025

Abstract excerpt

Improving treatment options for head and neck squamous cell carcinoma (HNSCC) requires a deeper understanding of the tumor microenvironment, particularly cancer-associated fibroblasts (CAFs). We previously reported that HNSCC-derived FGF2/bFGF (fibroblast growth factor 2) triggers cytokine release from CAFs via secretory autophagy. Here, using transmission electron microscopy, live-cell imaging, and...

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PMID: 40383937
DOI: 10.1080/15548627.2025.2508064

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