Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?

Abstract excerpt

INTRODUCTION: Age-related macular degeneration (AMD) is an eye disease leading to vision loss with poorly known pathogenesis and limited therapeutic options. Degradative autophagy (DA) is impaired in AMD, but emerging evidence points to secretary autophagy (SA) as a key element in AMD pathogenesis. AREAS COVERED: SA may cause the release of proteins and protein aggregates, lipofuscin, beta amyloid, faulty...

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