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Deciphering human endogenous retrovirus expression in colorectal cancers: exploratory analysis regarding prognostic value in liver metastases

16 May 2025

Abstract excerpt

BACKGROUND: Human Endogenous RetroVirus (HERV) expression in tumours reflects epigenetic dysregulation of cancer and an oncogenic factor through promoter/enhancer action on genes. While more than 50% of colorectal cancers develop liver metastases, HERV has not been studied in this context. METHODS: We collected 400 RNA-seq samples from over 200 patients with primary and liver metastases, including public data and...

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PMID: 40381378
DOI: 10.1016/j.ebiom.2025.105727

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