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Article

Identifying a role for oxytosis/ferroptosis in Pde6b-associated retinitis pigmentosa.

Experimental eye research - 1 Aug 2025

Weiss Madison E, Parrales Paola E, Datta Maumita, Fleishaker Michelle, Dvoriantchikova Galina, Ivanov Dmitry, Hackam Abigail S

Abstract excerpt

Inherited retinal diseases (IRDs) are a large heterogeneous group of diseases that lead to visual impairment and complete vision loss. Retinitis pigmentosa (RP) is an IRD with progressive degeneration of photoreceptors and has been associated with mutations in over 80 genes. In this study, we investigated the mechanism of retinal degeneration caused by an inherited mutation in the Pde6b gene in the rd10 mouse...

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Share to Cyclic Nucleotide Phosphodiesterases, Type 6
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroretinography

Share to Gene Expression Regulation

Share to Mice, Inbred C57BL

Share to Photoreceptor Cells, Vertebrate

Share to Retinitis Pigmentosa

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Source

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Identifiers

PMID: 40379200
DOI: 10.1016/j.exer.2025.110424
PMCID: PMC12148697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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