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Proteomics identifies multiple retinitis pigmentosa associated proteins involved in retinal degeneration in a mouse model bearing a Pde6b mutation.

Scientific reports - 27 Sept 2024

Yang Mingzhu, Qiu Ruiqi, Jin Xiuxiu, Yao Shun, Wang Weiping, Liu Jingyang, Liu Guangming, Han Jinfeng, Lei Bo

Abstract excerpt

Retinitis pigmentosa (RP) is a progressive and degenerative retinal disease resulting in severe vision loss. RP have been extensively studied for pathogenetic mechanisms and treatments. Yet there is little information about alterations of RP associated proteins in phosphodiesterase 6 beta (Pde6b) mutated model. To explore the roles of RP causing proteins, we performed a label free quantitative mass spectrometry...

Topics

Animals
Cyclic Nucleotide Phosphodiesterases, Type 6
Retinitis Pigmentosa
Proteomics
Mice
Disease Models, Animal
Mutation
Eye Proteins
Retinal Degeneration
Retina

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Identifiers

PMID: 39333705
DOI: 10.1038/s41598-024-72821-1
PMCID: PMC11437026

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