Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p In Vitro.

Tissue engineering and regenerative medicine - 1 Jul 2025

Lee JuHyeok, Lee Jiyoung, Choi Byung Hyune

Abstract excerpt

BACKGROUND: This study investigated anti-inflammatory effects of exosomes derived from human fetal cartilage progenitor cells (hFCPC-Exo) and their microRNAs (miRNAs) on the osteoarthritis (OA) phenotype in vitro in comparison with exosomes from bone marrow mesenchymal stem cells (MSC-Exo). METHODS: SW982 cells (synoviocytes) or hFCPCs (chondrocytes) were stimulated with 10 ng/mL IL-1β to mimic OA phenotypes. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exosomes

Share to Interleukin-1beta

Share to Mesenchymal Stem Cells

Share to MicroRNAs

Share to Osteoarthritis

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 40372627
DOI: 10.1007/s13770-025-00720-1
PMCID: PMC12209160

Genes

MSC
ACAN
COL2A1
MMP13
SOCS1
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p In Vitro.PMID 40372627Read ↗

Human Fetal Cartilage-Derived Progenitor Cells Exhibit Anti-Inflammatory Effect on IL-1β-Mediated Osteoarthritis Phenotypes In Vitro.Semantic proximity Read ↗

Comparisons of miRNA profiles of exosomes derived from human iPSCs, ADSCs, and BMSCs and effects on chondrocyte functionSemantic proximity Read ↗

Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cellsSemantic proximity Read ↗

Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization.Semantic proximity Read ↗

Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytesSemantic proximity Read ↗

Human Infrapatellar Fat Pad Mesenchymal Stem Cells Show Immunomodulatory Exosomal SignaturesSemantic proximity Read ↗

Amniotic Fluid-derived MSC Secretome Halts Action of IL-1β and TNF-α Through ERK/MAPK and Returns Cartilage Repair Under OA Inflammatory StimuliSemantic proximity Read ↗

Exosomes derived from primary cartilage stem/progenitor cells promote the repair of osteoarthritic chondrocytes by modulating immune responsesSemantic proximity Read ↗

Dental Follicle Mesenchymal Stem Cell-Derived Exosomes Mitigate Temporomandibular Joint Osteoarthritis in an In Vitro Model via the miR-146a-5p/Traf6/NF-κB AxisSemantic proximity Read ↗

Immunotherapy with Pro-regenerative Macrophages from Embryonic Stem Cells Ameliorate Osteoarthritis via TNFAIP3-Mediated ChondroprotectionSemantic proximity Read ↗

miRNA-Guided Regulation of Mesenchymal Stem Cells Derived from the Umbilical Cord: Paving the Way for Stem-Cell Based Regeneration and TherapySemantic proximity Read ↗

Exosomes Extracted from Human Umbilical Cord MSCs Contribute to Osteoarthritic Cartilage and Chondrocytes Repair Through Enhancing Autophagy While Suppressing the Wnt/β-Catenin PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.