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Amniotic Fluid-derived MSC Secretome Halts Action of IL-1β and TNF-α Through ERK/MAPK and Returns Cartilage Repair Under OA Inflammatory Stimuli

2021-12-20

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<title>Abstract</title> <p><bold>Background:</bold> Osteoarthritis (OA) is a degenerative cartilage disease. OA cartilage has a limited repair capacity due to the effect of IL-1β and TNF-α on the chondrocyte progenitor cells (CPC) in an OA joint. Mesenchymal stem cells (MSC) therapy is a therapeutic option for osteoarthritis that initiated by the ability of secretory growth factors and mediator molecules to heal...

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Literature Corpus work
6ffc894b-3ac6-5365-b472-819558aa7ba9
DOI
10.21203/rs.3.rs-1165634/v1
Open publication

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