Article
A Novel Rexinoid Agonist, UAB116, Decreases Metastatic Phenotype in Hepatoblastoma by Inhibiting the Wnt/β-Catenin Pathway via Upregulation of TRIM29.
International journal of molecular sciences - 22 Apr 2025
Butey Swatika, Brown Morgan L, Julson Janet R, Marayati Raoud, Atigadda Venkatram R, Shaikh Maryam G, Nazam Nazia, Quinn Colin H, Shirley Sorina, Stafman Laura L, Beierle Elizabeth A
Abstract excerpt
Hepatoblastoma (HB) is the most common pediatric primary liver tumor. About 20% of affected children have pulmonary metastasis at presentation. Survival rates for these children are dismal, not exceeding 25%. To study this subset of patients, we sequenced a metastatic HB cell line, HLM_2, and identified downregulation of the Liver X Receptor (LXR)/Retinoid X Receptor (RXR) pathway. LXR/RXRs function as...
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