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Post-genome-wide association study dissects genetic vulnerability and risk gene expression of Sjögren’s disease for cardiovascular disease

11 May 2025

Abstract excerpt

OBJECTIVES: This study aims to clarify the genetic associations between Sjögren's Disease (SD) and cardiovascular disease (CVD) outcomes, and to conduct an in-depth exploration of specific pleiotropic susceptibility genes. METHODS: We performed two-sample and multivariable Mendelian randomization (MR) analysis to investigate the association between SD and the risk of ischemic heart disease (IHD) and stroke....

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PMID: 40350475
DOI: 10.1186/s12967-025-06568-2

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