Article
Combining MYD88 L265P mutation detection and clonality determination on CSF cellular and cell-free DNA improves diagnosis of primary CNS lymphoma.
British journal of haematology - 1 Jun 2023
Bravetti Clotilde, Degaud Michaël, Armand Marine, Sourdeau Elise, Mokhtari Karima, Maloum Karim, Osman Jennifer, Verrier Patricia, Houillier Caroline, Roos-Weil Damien, Soussain Carole, Choquet Sylvain, Hoang-Xuan Khe, Le Garff-Tavernier Magali, Denis Jérôme Alexandre, Davi Frédéric
Abstract excerpt
Diagnosis of primary central nervous system lymphoma (PCNSL) is challenging, and although brain biopsy remains the gold standard, cerebrospinal fluid (CSF) constitutes a less invasive source of lymphomatous biomarkers. In a retrospective cohort of 54 PCNSL cases tested at diagnosis or relapse, we evaluated the contribution of immunoglobulin heavy chain (IGH) gene clonality and MYD88 L265P detection on both CSF...
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