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Article

Metabolic pathways mediating insulin resistance and gestational diabetes mellitus discovered by high-dimensional systematic Mendelian randomization.

Cardiovascular diabetology - 9 May 2025

Chen Wei, Luo Mingjuan, Guo Jingyi, Wang Suna, Yan Dandan, Feng Xiaohui, Huang Yunting, Zeng Tao, Shen Li, Zhang Rong, Yan Jing, Hu Cheng, Zhang Weituo, Yu Xiangtian

Abstract excerpt

BACKGROUND: Gestational diabetes mellitus (GDM), characterized by insulin resistance (IR) and β-cell dysfunction, is one of the most common complications of pregnancy with unmet needs of prevention methods. OBJECTIVE: To investigate the causal role of insulin resistance and metabolic pathways in the pathogenesis of GDM with our proposed high-dimensional systematic Mendelian randomization (hdsMR) framework....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40346526
DOI: 10.1186/s12933-025-02746-0
PMCID: PMC12065323

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