Article
Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury.
Clinical chemistry - 1 Dec 2013
Beck Julia, Bierau Sarah, Balzer Stefan, Andag Reiner, Kanzow Philipp, Schmitz Jessica, Gaedcke Jochen, Moerer Onnen, Slotta Jan E, Walson Philip, Kollmar Otto, Oellerich Michael, Schütz Ekkehard
Abstract excerpt
BACKGROUND: Cell-free DNA (cfDNA) from grafts in the circulation of transplant recipients is a potential biomarker of rejection. Its usefulness was investigated after heart transplantation during the maintenance phase by use of microarrays and massive parallel sequencing of donor and recipient DNA. Disadvantages of these methods are high costs, long turnaround times, and need for donor DNA. Therefore, we sought...
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