Article

Molecular Mechanisms of Erastin-Induced Ferroptosis in Human Ovarian Tumor Cells

2024-02-28

Abstract excerpt

Erastin (ER) induces cell death by utilizing the process of ferroptosis via generation of reactive oxygen species (ROS). Ferroptosis is characterized by accumulation of ROS within the cell, leading to an iron-dependent oxidative damage-mediated cell death. Here, we have examined ferroptosis-dependent mechanism(s) of cytotoxicity of ER in K-RAS mutant human ovarian tumor OVCAR-8 and NCI/ADR-RES cell lines. We used...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6a81fe3-30ac-5396-9787-5081b83a50c7
DOI: 10.20944/preprints202402.1608.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular Mechanisms of Erastin-Induced Ferroptosis in Human Ovarian Tumor CellsDOI 10.20944/preprints202402.1608.v1Read

Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics studySemantic proximity Read

Ferroptosis-Mediated Cell Death Induced by NCX4040, The Non-Steroidal Nitric Oxide Donor, in Human Colorectal Cancer Cells: Implications in TherapySemantic proximity Read

Insights Into Ferroptosis, a Novel Target for the Therapy of CancerSemantic proximity Read

Crosstalk between ferroptosis and endoplasmic reticulum stress: A potential target for ovarian cancer therapy (Review)Semantic proximity Read

JS-K induces ferroptosis in renal carcinoma cells by regulating the c-Myc-GSTP1 AxisSemantic proximity Read

Iron Administration Overcomes Resistance to Erastin-Mediated Ferroptosis in Ovarian Cancer CellsSemantic proximity Read

Effect of Ferroptosis Inducers and Inhibitors on Cell Proliferation in Acute LeukemiaSemantic proximity Read

Mechanism of Erastin-Induced Ferroptosis in MDA-MB-231 Human Breast Cancer Cells: Evidence for a Critical Role of Protein Disulfide IsomeraseSemantic proximity Read

Overview of Ferroptosis and Synthetic Lethality StrategiesSemantic proximity Read

Research progress on ferroptosis and PARP inhibitors in ovarian cancer: action mechanisms and resistance mechanismsSemantic proximity Read

Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosisSemantic proximity Read

Auranofin induces lethality driven by reactive oxygen species in high-grade serous ovarian cancer cellsSemantic proximity Read