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Application of natural products for inducing ferroptosis in tumor cells

4 Jan 2021

Abstract excerpt

Ferroptosis is a regulated cell death pathway based on the deposition of lipid-based reactive oxygen species (L-ROS) in the presence of iron ions. The term was first coined in 2012 by Dixon. Decreased glutathione (GSH) synthesis and low glutathione-dependent antioxidant peroxidase 4 (GPX4) activity are the major causes of ferroptosis. Sensitivity to ferroptosis for example in tumor cells may be further enhanced...

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PMID: 33393679
DOI: 10.1002/bab.2096

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