Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic association of social participation with cognitive function: A bidirectional Mendelian randomization study.

Journal of Alzheimer's disease : JAD - 1 Jul 2025

Zhai Aoqiang, Zou Ruiqi, Lv Tianrun, Yang Siqi, Zhong Yanjie, Xiong Yang, Li Fuyu, Hu Haijie

Abstract excerpt

BackgroundCognitive decline poses a significant challenge in aging societies. While some studies suggest that active social participation mitigates cognitive decline, others present conflicting findings.ObjectiveThis bidirectional two-sample Mendelian randomization (MR) study aimed to elucidate the causal relationship between social participation and cognitive function.MethodsThe cognitive performance dataset...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to Cognitive Dysfunction

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 40329559
DOI: 10.1177/13872877251340078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic association of social participation with cognitive function: A bidirectional Mendelian randomization study.PMID 40329559Read ↗

Social Isolation, Social Interaction, and Alzheimer's Disease: A Mendelian Randomization Study.Semantic proximity Read ↗

Association of loneliness, social isolation, and neuroticism in Alzheimer’s disease risk: a two-step Mendelian randomization studySemantic proximity Read ↗

Using a two-sample mendelian randomization analysis to explore the relationship between physical activity and Alzheimer's disease.Semantic proximity Read ↗

A Phenome-wide Association and Mendelian Randomization Study for Alzheimer's Disease: A Prospective Cohort Study of 502,493 Participants From the UK Biobank.Semantic proximity Read ↗

Walking to protect against cognitive decline: the role of APOE genotype and sex.Semantic proximity Read ↗

Genetic insights into the causal relationship between physical activity and cognitive functioning.Semantic proximity Read ↗

Exercise may delay cognitive decline in Chinese older adults: a causal inference for ordered multi-categorical exposures with a Mendelian randomization approach.Semantic proximity Read ↗

Causal associations between socioeconomic status and Alzheimer’s disease: a Mendelian randomization and Mediation AnalysisSemantic proximity Read ↗

Genetically-predicted effects of lifestyle factors on frailty: Evidence from Mendelian randomization studySemantic proximity Read ↗

Assessment of causal effects of physical activity on neurodegenerative diseases: A Mendelian randomization studySemantic proximity Read ↗

Physical activity and risk of Alzheimer’s disease: a two-sample Mendelian randomization studySemantic proximity Read ↗

Assessment of Bidirectional Relationships between Frailty and Mental Disorders: A Bidirectional Mendelian Randomization StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.