Frontobasal gray matter loss is associated with the TREM2 p.R47H variant.

doi:10.1016/j.neurobiolaging.2014.06.007

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Article

Frontobasal gray matter loss is associated with the TREM2 p.R47H variant.

Neurobiology of aging - 1 Dec 2014

Luis Elkin O, Ortega-Cubero Sara, Lamet Isabel, Razquin Cristina, Cruchaga Carlos, Benitez Bruno A, Lorenzo Elena, Irigoyen Jaione, Pastor Maria A, Pastor Pau

Abstract excerpt

A rare heterozygous TREM2 variant p.R47H (rs75932628) has been associated with an increased risk for Alzheimer's disease (AD). We aimed to investigate the clinical presentation, neuropsychological profile, and regional pattern of gray matter and white matter loss associated with the TREM2 variant p.R47H, and to establish which regions best differentiate p.R47H carriers from noncarriers in 2 sample sets (Spanish...

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Identifiers

PMID: 25027412
DOI: 10.1016/j.neurobiolaging.2014.06.007
PMCID: PMC4253600

Genes

TREM2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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