Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263

12 Mar 2022

Abstract excerpt

Radiotherapy (RT) is a key component of cancer treatment. Although improvements have been made over the years, radioresistance remains a challenge. For this reason, a better understanding of cell fates in response to RT could improve therapeutic options to enhance cell death and reduce adverse effects. Here, we showed that combining RT (photons and protons) to noncytotoxic concentration of PARP inhibitor,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35326611
DOI: 10.3390/cancers14061460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263PMID 35326611Read ↗

Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent CellsSemantic proximity Read ↗

Biochemical and Cellular Characterization of New Radio-Resistant Cell Lines Reveals a Role of Natural Flavonoids to Bypass SenescenceSemantic proximity Read ↗

DNA Damage- But Not Enzalutamide-Induced Senescence in Prostate Cancer Promotes Senolytic Bcl-xL Inhibitor SensitivitySemantic proximity Read ↗

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescenceSemantic proximity Read ↗

Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiationSemantic proximity Read ↗

PARP inhibitors induce a senescence phenotype in non-small cell lung carcinoma cell lines.Semantic proximity Read ↗

Sorafenib, rapamycin, and venetoclax attenuate doxorubicin-induced senescence and promote apoptosis in HCT116 cellsSemantic proximity Read ↗

The PARP inhibitor olaparib promotes senescence in murine macrophagesSemantic proximity Read ↗

The Roles of Autophagy and Senescence in the Tumor Cell Response to RadiationSemantic proximity Read ↗

Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin.Semantic proximity Read ↗

Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cellsSemantic proximity Read ↗

Novel senolytic and senescence-suppressing compounds overcome senescence-driven chemoresistance in NSCLCSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.