Colonoscopy findings in CDH1 carriers from a multicenter international study.

doi:10.1007/s10689-025-00466-8

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Colonoscopy findings in CDH1 carriers from a multicenter international study.

Familial cancer - 5 May 2025

Chatterjee Arjun, Hüneburg Robert, Yang Qijun, Morrison Shannon, Bettzüge Anna, Marwitz Tim, Aretz Stefan, Spier Isabel, Ripperger Tim, Redler Silke, Kachanov Mykyta, Volk Alexander E, Vangala Deepak B, Daum Severin, Holinski-Feder Elke, Steinke-Lange Verena, Bahlke Kathrin, Strassburg Christian P, MejiaPerez Lady Katherine, O'Malley Margaret M, LaGuardia Lisa, Liska David, Macaron Carole, Sommovilla Joshua, Burke Carol A, Nattermann Jacob

Abstract excerpt

Germline (likely-)pathogenic variants (PV) in CDH1 predispose carriers to hereditary diffuse gastric cancer and lobular breast cancer. Previous studies from the United States suggest CDH1 variant carriers have an increased risk for adenomas or sessile serrated lesions (SSL), yet data linking CDH1 PVs and colorectal neoplasia are scarce. We aimed to investigate colonoscopy findings in CDH1 PVs. Adults carrying a...

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Identifiers

PMID: 40323501
DOI: 10.1007/s10689-025-00466-8
PMCID: PMC12052908

Genes

CDH1

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