Article
Parity, breastfeeding, and the risk of early-onset breast cancer in women with a BRCA1 pathogenic variant.
British journal of cancer - 1 Jul 2025
Kotsopoulos Joanne, Maxwell Christopher A, Lubinski Jan, Huzarski Tomasz, Kim Raymond H, Tung Nadine, Eisen Andrea, Foulkes William, Aeilts Amber, Neuhausen Susan L, Bordeleau Louise, Khokha Rama, Pal Tuya, Karlan Beth, Fruscio Robert, Couch Fergus, Sun Ping, Gronwald Jacek, Narod Steven A
Abstract excerpt
BACKGROUND: It is not clear if breastfeeding and/or parity are associated with the risk of breast cancer among women with a germline pathogenic variant in BRCA1. We sought to evaluate the associations of these two factors with early-onset breast cancer in the BRCA1 pathogenic variant. METHODS: This case-control study included individuals with a BRCA1 pathogenic variant enroled in a longitudinal study using...
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