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Imprint of parity and age at first pregnancy on the genomic landscape of subsequent breast cancer

15 Feb 2019

Abstract excerpt

Although parity and age at first pregnancy are among the most known extrinsic factors that modulate breast cancer risk, their impact on the biology of subsequent breast cancer has never been explored in depth. Recent data suggest that pregnancy-induced tumor protection is different according to breast cancer subtypes, with parity and young age at first pregnancy being associated with a marked reduction in the...

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PMID: 30770770
DOI: 10.1186/s13058-019-1111-6

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