Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers.

doi:10.1007/s10549-009-0394-1

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Article

Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers.

Breast cancer research and treatment - 1 Jan 2010

Milne Roger L, Osorio Ana, Ramón y Cajal Teresa, Baiget Montserrat, Lasa Adriana, Diaz-Rubio Eduardo, de la Hoya Miguel, Caldés Trinidad, Teulé Alex, Lázaro Conxi, Blanco Ignacio, Balmaña Judith, Sánchez-Ollé Gessamí, Vega Ana, Blanco Ana, Chirivella Isabel, Esteban Cardeñosa Eva, Durán Mercedes, Velasco Eladio, Martínez de Dueñas Eduardo, Tejada María-Isabel, Miramar María-Dolores, Calvo María-Teresa, Guillén-Ponce Carmen, Salazar Raquel, San Román Carlos, Urioste Miguel, Benítez Javier

Abstract excerpt

Environmental or lifestyle factors are likely to explain part of the heterogeneity in breast and ovarian cancer risk among BRCA1 and BRCA2 mutation carriers. We assessed parity as a risk modifier in 515 and 503 Spanish female carriers of mutations in BRCA1 and BRCA2, respectively. Hazard ratios (HR) and their corresponding 95% confidence intervals (CI) were estimated using weighted Cox proportional hazards...

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Identifiers

PMID: 19370414
DOI: 10.1007/s10549-009-0394-1

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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