Article
Pregnancies, breast-feeding, and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (IBCCS).
Journal of the National Cancer Institute - 19 Apr 2006
Andrieu Nadine, Goldgar David E, Easton Douglas F, Rookus Matti, Brohet Richard, Antoniou Antonis C, Peock Susan, Evans Gareth, Eccles Diana, Douglas Fiona, Noguès Catherine, Gauthier-Villars Marion, Chompret Agnès, Van Leeuwen Flora E, Kluijt Irma, Benitez Javier, Arver Brita, Olah Edith, Chang-Claude Jenny
Abstract excerpt
BACKGROUND: Multiparity, young age at first childbirth, and breast-feeding are associated with a reduced risk of breast cancer in the general population. The breast cancer predisposition gene, BRCA1, regulates normal cell differentiation. Because mammary gland cells divide and differentiate durin...
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