Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Linking p53 rs1042522 Variant to Thyroid Cancer Risk: Insights from a Comprehensive Meta-Analysis of 2116 Cases.

Cancer investigation - 1 Feb 2026

Vakili-Ojarood Mohammad, Shirinzadeh-Dastgiri Ahmad, Meybodian Mojtaba, Barahman Maedeh, Alijanpour Abolhasan, Khosravi-Mashizi Mehdi, Haghighikian Seyed Masoud, Naseri Amirhosein, Rahmani Amirhossein, Aghasipour Maryam, Aghili Kazem, Neamatzadeh Hossein

Abstract excerpt

This meta-analysis investigates the association between the p53 rs1042522 polymorphism and thyroid cancer, analyzing 18 case-control studies with 2,116 cases and 4,017 controls. It finds that the C allele is linked to a higher cancer risk (OR 1.572, 95% CI: 1.062-2.326, p = 0.024) but shows significant heterogeneity (I2 = 94.15%). Subgroup analyses indicate protective effects in Caucasian, Asian, and mixed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to Thyroid Neoplasms

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 41347628
DOI: 10.1080/07357907.2025.2596853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linking p53 rs1042522 Variant to Thyroid Cancer Risk: Insights from a Comprehensive Meta-Analysis of 2116 Cases.PMID 41347628Read ↗

Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-analysis.Semantic proximity Read ↗

Association between a single nucleotide polymorphism in the TP53 region and risk of ovarian cancer.Semantic proximity Read ↗

Association between rs735482 polymorphism and risk of cancer: A meta-analysis of 10 case-control studies.Semantic proximity Read ↗

The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.Semantic proximity Read ↗

Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis.Semantic proximity Read ↗

Genetic Polymorphism Predisposing to Differentiated Thyroid Cancer: A Review of Major Findings of the Genome-Wide Association StudiesSemantic proximity Read ↗

Association of rs6983267 Polymorphism and Thyroid Cancer Susceptibility: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

A novel TP53 variant (rs78378222 A > C) in the polyadenylation signal is associated with increased cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

Genetic polymorphisms of TP53 (rs1042522) and MDM2 (rs2279744) and colorectal cancer risk: An updated meta-analysis based on 59 case-control studies.Semantic proximity Read ↗

The effect of TP53 and P21 gene polymorphisms on papillary thyroid carcinoma susceptibility and clinical/pathological features.Semantic proximity Read ↗

Association between the TP53BP1 rs2602141 A/C polymorphism and cancer risk: a systematic review and meta-analysis.Semantic proximity Read ↗

Association between TP73 G4C14-A4T14 polymorphism and different cancer types: an updated meta-analysis of 55 case-control studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.