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Article

Oxygen regulates proliferation and phenotype in the RS0 SDH-deficient pheochromocytoma cell line.

Endocrine-related cancer - 1 Jun 2025

Powers James F, Cochran Brent, Baleja James D, Lomakin Inna, Zhang Xue, Shepard-Barry Annette, Tischler Arthur S

Abstract excerpt

The RS0 cell line is a rat-derived pheochromocytoma line developed as a model to study pheochromocytoma/paraganglioma caused by hereditary mutations of the SDHB gene. Previous studies demonstrated that xenografts of the RS0 parent tumor replicate characteristics of their human counterparts, including loss of SDHB and upregulation of genes in hypoxia signaling pathways activated by EPAS1/HIF2A. Establishment of...

Read the complete abstract on PubMed

Topics

Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Pheochromocytoma

Rats

Cell Proliferation

Adrenal Gland Neoplasms

Cell Line, Tumor

Oxygen

Succinate Dehydrogenase

Phenotype

Basic Helix-Loop-Helix Proteins

Humans

Mice

Endothelial PAS Domain-Containing Protein 1

Source

Identifiers

PMID: 40310702
DOI: 10.1530/ERC-25-0022

Genes

EPAS1
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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