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Article

Metabolic pathways in sporadic colorectal carcinogenesis: A new proposal.

Medical hypotheses - 1 Mar 2021

Caramujo-Balseiro Sandra, Faro Carlos, Carvalho Lina

Abstract excerpt

Given the reports made about geographical differences in Colorectal Cancer (CRC) occurrence, suggesting a link between dietary habits, genes and cancer risk, we hypothesise that there are four fundamental metabolic pathways involved in diet-genes interactions, directly implicated in colorectal carcinogenesis: folate metabolism; lipid metabolism; oxidative stress response; and inflammatory response. Supporting...

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PMID: 33548761
DOI: 10.1016/j.mehy.2021.110512

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