Article
Isolation and characterization of capsule structure mutant strains of Cryptococcus neoformans.
Molecular microbiology - 1 Aug 2002
Moyrand Frédérique, Klaproth Birgit, Himmelreich Uwe, Dromer Françoise, Janbon Guilhem
Abstract excerpt
The capsule of Cryptococcus neoformans is the most obvious virulence factor of this pathogenic yeast. The main capsule constituents are glucuronoxylomannans (GXM). Although several studies have focused on GXM composition and structure, very little is known about their genetics. To elucidate the relationship between the capsule structure and the pathophysiology of the cryptococcosis, genetic screening for mutant...
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