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Capsule Structural Heterogeneity and Antigenic Variation in Cryptococcus neoformans

29 Jun 2007

Abstract excerpt

Cryptococcus neoformans is a human pathogenic fungus with a capsule composed primarily of glucuronoxylomannan (GXM) that is important for virulence. Current views of GXM structure postulate a polymer composed of repeating mannose trisaccharide motifs bearing a single beta(1,2) glucuronic acid with variable xylose and O-acetyl substitutions to form six triads. GXM from different strains is notoriously variable in...

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PMID: 17601878
DOI: 10.1128/ec.00162-07

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