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Article

Impacts of Pharmacokinetic Gene Polymorphisms on Steady-State Plasma Concentrations of Simvastatin in Thai Population.

Clinical and translational science - 1 May 2025

Tipnoppanon Sayanit, Udomnilobol Udomsak, Siwamogsatham Sarawut, Vorasettakarnkij Yongkasem, Sukasem Chonlaphat, Prueksaritanont Thomayant, Chariyavilaskul Pajaree, Yodsurang Varalee, Srimatimanon Thanate, Chamnanphon Monpat, Vanwong Natchaya

Abstract excerpt

Simvastatin, an HMG-CoA reductase inhibitor, is widely used for hypercholesterolemia but may cause myotoxicity linked to its plasma concentration. Pharmacokinetic gene polymorphisms influence inter-individual variability in simvastatin exposure. This study investigated the effects of pharmacokinetic gene polymorphisms on steady-state simvastatin plasma levels in Thai patients. Eighty-nine Thai patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40297930
DOI: 10.1111/cts.70225
PMCID: PMC12038368

Genes

SLCO1B1
ABCB1
ABCC2
ABCG2
CYP3A4
CYP3A5
SLCO1B3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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