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Article

Genetic variety of ORF3a shapes SARS‐CoV‐2 fitness through modulation of lipid droplet

1 Mar 2023

Abstract excerpt

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leads to the accumulation of lipid droplets (LD), the central hubs of the lipid metabolism, in vitro or in type II pneumocytes and monocytes from coronavirus disease 19 (COVID-19) patients and blockage of LD formation by specific inhibitors impedes SARS-CoV-2 replication. Here, we showed that ORF3a is necessary and sufficient to trigger LD...

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PMID: 36861654
DOI: 10.1002/jmv.28630

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