Article
Stress-related genetic components in attention-deficit/hyperactivity disorder (ADHD): Effects of the SERPINA6 and SERPINA1 genetic markers in a family-based brazilian sample.
Journal of psychiatric research - 1 May 2022
Carpena Marina Xavier, Sánchez-Luquez Karen Yumaira, Martins-Silva Thais, Santos Thiago M, Farias Cid Pinheiro, Leventhal Daniel Gray Paschoal, Berruti Barbara, Zeni Cristian Patrick, Schmitz Marcelo, Chazan Rodrigo, Hutz Mara H, Salatino-Oliveira Angélica, Genro Julia P, Rohde Luis Augusto, Tovo-Rodrigues Luciana
Abstract excerpt
SERPINA6 and SERPINA1 were recently identified as the main genes associated with plasma cortisol concentration in humans. Although dysregulation in the Hypothalamus-Pituitary-Adrenal (HPA) axis has been observed in Attention Deficit/Hyperactivity Disorder (ADHD), the molecular mechanisms underlying this relationship are still unclear. Evaluation of the SERPINA6/SERPINA1 gene cluster in ADHD may provide relevant...
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