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Article

DNA methylation and 28 year incidence of two neuropathy phenotypes in type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications cohort study.

Diabetologia - 1 Jul 2025

Zhou Jiayi, Mychaleckyj Josyf C, Onengut-Gumuscu Suna, Orchard Trevor J, Costacou Tina, Miller Rachel G

Abstract excerpt

AIMS/HYPOTHESIS: Diabetic peripheral neuropathy (DPN) and neuropathic pain (NP) are common complications of type 1 diabetes that can greatly affect quality of life. Studying DNA methylation (DNAm) may help identify potential therapeutic targets; however, epigenome-wide association studies (EWAS) of DPN and NP are lacking. We thus performed prospective EWAS of 28 year DPN and NP incidence in the Pittsburgh...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40266295
DOI: 10.1007/s00125-025-06427-1
PMCID: PMC12766922

Genes

PKNOX1
CACNA1B
CHMP6

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