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DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes

5 Apr 2020

Abstract excerpt

BACKGROUND: Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-tissue and Skin & Blood try to estimate chronological age in the normal population whereas PhenoAge and GrimAge use surrogate markers associated with mortality to estimate biological age and its...

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PMID: 32248841
DOI: 10.1186/s13148-020-00840-6

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