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Comprehensive Constitutional Genetic and Epigenetic Characterization of Lynch-Like Individuals

5 Jul 2020

Abstract excerpt

The causal mechanism for cancer predisposition in Lynch-like syndrome (LLS) remains unknown. Our aim was to elucidate the constitutional basis of mismatch repair (MMR) deficiency in LLS patients throughout a comprehensive (epi)genetic analysis. One hundred and fifteen LLS patients harboring MMR-deficient tumors and no germline MMR mutations were included. Mutational analysis of 26 colorectal cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32635641
DOI: 10.3390/cancers12071799

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