Article

Loss of SARM1 protects against retinal ganglion cell degeneration in Autosomal Dominant Optic Atrophy

2024-10-02

Abstract excerpt

<h4>Summary</h4> Autosomal Dominant Optic Atrophy (ADOA), the most prevalent inherited optic neuropathy, leads to retinal ganglion cell (RGC) degeneration and vision loss. ADOA is primarily caused by mutations in the OPA1 gene, which encodes a conserved GTPase important for mitochondrial inner membrane dynamics. To date, the disease mechanism remains unclear, and no therapies are available. Here, we present a no...

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Literature Corpus work: ae5844bc-76ce-5509-9700-fc9a18fad92b
DOI: 10.1101/2024.09.30.615936

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