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Article

Epigenomic regulation of stemness contributes to the low immunogenicity of the most mutated human cancer

17 Apr 2025

Abstract excerpt

Despite harboring the highest tumor mutational burden of all cancers, basal cell carcinoma (BCC) has low immunogenicity. Here, we demonstrate that BCC's low immunogenicity is associated with epigenomic suppression of antigen presentation machinery reminiscent of its cell of origin. Primary BCC had low T cell infiltrates and low human leukocyte antigen class I (HLA-I) expression compared with cutaneous squamous...

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PMID: 40250424
DOI: 10.1016/j.celrep.2025.115561

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