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Identified BIRC5 and HDAC1 as Novel Diagnostic Biomarkers Linked to Centrosome-Immune Crosstalk for Cutaneous Squamous Cell Carcinoma via Machine Learning-Based Multi-omics Analysis

2025-11-12

Abstract excerpt

<title>Abstract</title> <p>Background Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer where immune dysregulation plays a critical role in its progression and resistance to therapy. Centrosomal amplification (CA), a marker of genomic instability, contributes to cancer development by affecting cell division, immune cell activation, antigen presentation, and cytokine signaling. Further research into...

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Literature Corpus work
8b7acdde-89b8-54b5-aa47-9f5e9b27a540
DOI
10.21203/rs.3.rs-7496212/v1
Open publication

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Identified BIRC5 and HDAC1 as Novel Diagnostic Biomarkers Linked to Centrosome-Immune Crosstalk for Cutaneous Squamous Cell Carcinoma via Machine Learning-Based Multi-omics AnalysisDOI 10.21203/rs.3.rs-7496212/v1
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