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Article

TP53 somatic evolution in the normal endometrium of Black and White individuals.

Gynecologic oncology - 1 Jun 2025

Rios-Doria Eric, Parker Elizabeth U, Kohrn Brendan F, Pike Mindy, Coombes Coohleen, Latorre-Esteves Elena, Reiter Daniel J, Fredrickson Jeanne, Katz Ronit, Swisher Elizabeth M, Doll Kemi M, Risques Rosa Ana

Abstract excerpt

BACKGROUND: TP53 mutations are the main drivers of aggressive, high-risk endometrial carcinomas commonly diagnosed in Black individuals. However, TP53 mutations have also been identified in benign, non-cancerous tissues. We sought to understand the TP53 mutational landscape in benign endometrium throughout the lifespan of Black and White individuals, accounting for structural socioeconomic context. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40250028
DOI: 10.1016/j.ygyno.2025.04.002
PMCID: PMC13383288

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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