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Exploring the Genetic Link between Irritable Bowel Syndrome and Polycystic Ovary Syndrome: Bidirectional Mendelian Randomization and Machine Learning Approaches

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Gao Ziwei, Mei Zhenglin, Zhang Yujun, Lv Siyao, Song Jingru, Ye Wei

Abstract excerpt

BACKGROUND: Research has shown a certain correlation between polycystic ovary syndrome (PCOS) and irritable bowel syndrome (IBS). The study aims to determine the directionality and underlying biological processes influencing the relationship between these two disorders. METHODS: We explored the causal relationship between IBS and PCOS by conducting a comprehensive bidirectional Mendelian randomization (MR)...

Read the complete abstract on PubMed

Topics

Polycystic Ovary Syndrome
Humans
Irritable Bowel Syndrome
Female
Mendelian Randomization Analysis
Machine Learning

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Protein Interaction Maps

Source

Identifiers

PMID: 40247811
DOI: 10.2174/0118715303363459250317084005

Genes

CASP1
CD14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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