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Article

Causal Relationship Between Polycystic Ovary Syndrome and Autoimmune Diseases: A Two-Sample Mendelian Randomization Study.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 May 2025

Xing Xiuye, Wei Dachao, Lu Qun

Abstract excerpt

PROBLEM: Polycystic ovary syndrome (PCOS) is known to be associated with immune response dysregulation, resembling autoimmune diseases. However, the causal relationship between PCOS and autoimmune diseases remains unclear. METHODS: A two-sample bidirectional Mendelian randomization (MR) analysis was conducted using publicly available genome-wide association study (GWAS) data. The primary causal effects were...

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PMID: 40388209
DOI: 10.1111/aji.70083

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