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Association between psychiatric disorders and irritable bowel syndrome: A bidirectional Mendelian randomization study.

Journal of affective disorders - 1 Jan 2025

Wang Fan, Liu Yi-Long, Jiang Chun-Hui, Wu Hong-Yu, Jin Jing, Sun Yu-Wei, He Zi-Xuan, Kang Le, Fang Xue

Abstract excerpt

OBJECTIVE: Previous studies have suggested that irritable bowel syndrome (IBS) is strongly associated with psychiatric disorders. However, it is unclear whether this association is causal, concomitant, or accidental. Thus, we performed Mendelian randomization (MR) analysis to evaluate the causal effects of several psychiatric disorders on IBS. METHODS: Summary data of genome-wide association studies (GWASs) were...

Topics

Humans
Irritable Bowel Syndrome
Mendelian Randomization Analysis
Genome-Wide Association Study
Schizophrenia
Bipolar Disorder
Mental Disorders
Panic Disorder
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Depressive Disorder, Major

Stress Disorders, Post-Traumatic

Source

Identifiers

PMID: 39260576
DOI: 10.1016/j.jad.2024.09.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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