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Article

Genetic Drivers of Quality of Life in Prostate Cancer: An Evaluation of Genetic Polymorphisms and Patient-reported Outcomes in the E3805 CHAARTED trial.

European urology oncology - 1 Apr 2026

Sentana-Lledo Daniel, Chu Xiangying, Ryan Charles J, Gupta Arjun, Sweeney Christopher J, Jarrard David F, Plimack Elizabeth R, Gartrell Benjamin A, Carducci Michael A, Hussain Maha, Garcia Jorge A, Cella David, DiPaola Robert S, Pomerantz Mark, Morgans Alicia K

Abstract excerpt

BACKGROUND AND OBJECTIVE: The rs4680 single-nucleotide polymorphism (SNP) of the COMT gene leads to a reduction in dopamine clearance, resulting in better mood and a decrease in symptoms in noncancer populations, but its influence on quality of life (QOL) during cancer treatment is undefined. We hypothesized that in comparison to wildtype (WT) COMT, the rs4680 SNP is associated with better QOL among men with...

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Identifiers

PMID: 40246610
DOI: 10.1016/j.euo.2025.04.003
PMCID: PMC12371474

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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