Article
Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism?
BMC urology - 2 Aug 2016
Karunasinghe Nishi, Zhu Yifei, Han Dug Yeo, Lange Katja, Zhu Shuotun, Wang Alice, Ellett Stephanie, Masters Jonathan, Goudie Megan, Keogh Justin, Benjamin Benji, Holmes Michael, Ferguson Lynnette R
Abstract excerpt
BACKGROUND: Androgen deprivation therapy (ADT) is an effective palliation treatment in men with advanced prostate cancer (PC). However, ADT has well documented side effects that could alter the patient's health-related quality of life (HRQoL). The current study aims to test whether a genetic stratification could provide better knowledge for optimising ADT options to minimize HRQoL effects. METHODS: A cohort of...
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