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Article

The genetic variants underlying breast cancer treatment-induced chronic and late toxicities: a systematic review.

Cancer treatment reviews - 1 Dec 2014

Ng Terence, Chan Mint, Khor Chiea Chuen, Ho Han Kiat, Chan Alexandre

Abstract excerpt

A systematic review was performed to describe the findings from 19 genetic association studies that have examined the genetic variants underlying four common treatment-induced chronic and late toxicities in breast cancer patients, and to evaluate the quality of reporting. Three out of 5 studies found an association between HER2 lle655Val polymorphisms and trastuzumab-induced cardiotoxicity. Two studies found a...

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Identifiers

PMID: 25458605
DOI: 10.1016/j.ctrv.2014.10.001

Genes

COMT
CYP2C8
IL6
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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