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Article

Androgen deprivation therapy and cognitive decline-associations with brain connectomes, endocrine status, and risk genotypes.

Prostate cancer and prostatic diseases - 1 Feb 2022

Buskbjerg Cecilie R, Amidi Ali, Buus Simon, Gravholt Claus H, Hadi Hosseini S M, Zachariae Robert

Abstract excerpt

BACKGROUND: Evidence suggests that prostate cancer (PC) patients undergoing androgen deprivation therapy (ADT) are at risk for cognitive decline (CD), but the underlying mechanisms are less clear. In the present study, changes in cognitive performance and structural brain connectomes in PC patients undergoing ADT were assessed, and associations of cognitive changes with endocrine status and risk genotypes were...

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Source

Identifiers

PMID: 34088994
DOI: 10.1038/s41391-021-00398-1

Genes

PC
COMT
APOE
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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