A spectral framework to map QTLs affecting joint differential networks of gene co-expression.

Abstract excerpt

Studying the mechanisms underlying the genotype-phenotype association is crucial in genetics. Gene expression studies have deepened our understanding of the genotype  →  expression  →  phenotype mechanisms. However, traditional expression quantitative trait loci (eQTL) methods often overlook the critical role of gene co-expression networks in translating genotype into phenotype. This gap highlights the need for...

Topics

• Quantitative Trait Loci
• Gene Regulatory Networks
• Animals
• Computational Biology
• Chromosome Mapping
• Phenotype