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Article

Evolution of the bovine TLR gene family and member associations with Mycobacterium avium subspecies paratuberculosis infection.

PloS one - 1 Jan 2011

Fisher Colleen A, Bhattarai Eric K, Osterstock Jason B, Dowd Scot E, Seabury Paul M, Vikram Meenu, Whitlock Robert H, Schukken Ynte H, Schnabel Robert D, Taylor Jeremy F, Womack James E, Seabury Christopher M

Abstract excerpt

Members of the Toll-like receptor (TLR) gene family occupy key roles in the mammalian innate immune system by functioning as sentries for the detection of invading pathogens, thereafter provoking host innate immune responses. We utilized a custom next-generation sequencing approach and allele-specific genotyping assays to detect and validate 280 biallelic variants across all 10 bovine TLR genes, including 71...

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Source

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Identifiers

PMID: 22164200
DOI: 10.1371/journal.pone.0027744
PMCID: PMC3227585

Genes

TLR3
TLR8
TLR10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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