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Article

Genome alteration of Leishmania orientalis under Amphotericin B inhibiting conditions.

PLoS neglected tropical diseases - 1 Dec 2024

Anuntasomboon Pornchai, Siripattanapipong Suradej, Unajak Sasimanas, Choowongkomon Kiattawee, Burchmore Richard, Leelayoova Saovanee, Mungthin Mathirut, E-Kobon Teerasak

Abstract excerpt

Amphotericin B (AmB) is a potent antifungal and antiparasitic medication that exerts its action by disrupting the cell membrane of the leishmanial parasite, leading to its death. Understanding the genetic alterations induced by Amphotericin B is crucial for gaining insights into drug resistance mechanisms and developing more effective treatments against Leishmania infections. As a new Leishmania species, the...

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Identifiers

PMID: 39689148
DOI: 10.1371/journal.pntd.0012716
PMCID: PMC11687891

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