Genome analyses of amphotericin B-susceptible and -resistant strains of Leishmania (Mundinia) martiniquensis reveal variations potentially related to amphotericin B resistance

Abstract excerpt

Amphotericin B deoxycholate (AmpB) is used for the treatment of leishmaniasis caused by Leishmania ( Mundinia ) martiniquensis in Thailand, and relapse cases have been documented. To date, genomic analysis of drug-resistant L . martiniquensis strains is limited. In this study, comparative genome analyses were performed with an experimentally selected AmpB-resistant L . martiniquensis (AmpBRP2i) and two...

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