Article
Appraising the causal relevance of maternal red blood cell folate and congenital heart disease in offspring: 2-sample Mendelian randomization.
Annals of epidemiology - 1 Jun 2025
Chen Hongyan, Chen Xiaotian, Yao Qinyu, Xin Jibin, Zhang Yi, Huang Xiangyuan, Wang Dingmei, Li Mengru, Zhang Tiansong, Tillmann Taavi, Yan Weili, Huang Guoying
Abstract excerpt
PURPOSE: We performed a 2-sample Mendelian randomization (MR) using maternal MTHFR C677T as the genetic instrument to validate the causal association between maternal red blood cell (RBC) folate and offspring congenital heart disease (CHD) risk. METHODS: We obtained the genetic association for RBC folate through pooling data from 2 genome-wide association studies (the Trinity Student Study [n = 2229]) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.